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nucleatum may contribute to epithelial–mesenchymal transition (EMT), so it is tightly associated with cancer cell invasion, suppression of antitumor immune responses, stemness, and treatment resistance ( Enterotoxigenic Bacteroides fragilis (ETBF) that produces the metalloprotease Bacteroides fragilis toxin (BFT) promotes inflammation and disrupts the intestinal barrier function by targeting the tight junctions of intestinal epithelial cells (IECs), which is associated with acute diarrhea and inflammatory bowel disease ( 2.2 Gut microbiota also promotes extraintestinal cancers through bacterial translocation and production of bioactive molecules into circulation Organs outside of the gastrointestinal tract are also remotely affected by the gut microbiota’s carcinogenic effects

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